大学院生の研究教育内容と指導実績

（１）研究教育内容

大学院は、より良き医師となるための医学、医療の教育の場であると同時に、将来に役立つ科学的探究心を養う場でもあります。特に、研究を通して科学者の心を養うことは、今後の医師としての歩みの土台となります。医学博士は、医師の経歴の一つとしても大変大事なものですが、そのためには研究テーマに基づく学位論文を作成する必要があります。当科では、基礎と臨床を繋ぐTranslational researchの視点から、最先端の技術を用い、主に癌の診断と治療に関して以下のテーマで研究を行っています。

１．癌微小転移の遺伝子診断法の開発
２．癌幹細胞のプロファイル解析と癌治療への応用
３．microRNA発現と転移カスケードの解析
４. 癌の化学療法、分子標的薬、放射線療法における治療効果予測法の開発
５．癌免疫療法の開発
６．iPS細胞を用いた再生医療

（２）大学院生指導実績

これまで外科学講座大学院生２４名の学位指導をさせていただき、全員が医学博士を取得しています。このうち１３名の学位論文が英文国際誌に掲載され、３名が学会奨励賞を受賞しています。

研究室紹介

当科には研究専任スタッフ、田村純子（研究助手）がおります。研究に必要な実験手技、研究の進め方、論文作成など、卒業時までに学位がとれるよう、大学院生の皆様の研究を全面的にサポートします。外科研究室は、今年（平成２４年）４月に完成した、新大学棟の８階にあります。非常に綺麗なスペースで、最先端の実験機器が揃ったすばらしい研究環境が用意されています（写真１，２，３）。

insei2
insei3
insei1

研究室実績

これまで、多くの英文誌論文等の業績をもち、今年（2012年）の第50回日本癌治療学会総会では優秀演題賞(JSCO賞)を受賞しました。東大、九大、阪大など、他大学との共同研究も長年行っており、海外からも共同研究の依頼を受けています。以下に業績の一部(2010年から2012年10月まで)を記載します。

1. The rs6983267 SNP Is Associated with MYC Transcription Efficiency Which Promotes Progression and Worsens Prognosis of Colorectal Cancer. Takatsuno Y, IinumaH et al. Ann SurgOncolOnline14 september, 2012 (査読有：以下有と略す)

2. Accurate and rapid novel genetic diagnosis for detection of sentinel lymph node metastasis in breast cancer patients. Iinuma H, Fukushima R et al. Br J Cancer 107:724-731, 2012 (有)

3. Multicenter phase II clinical trial of cancer vaccination for advanced esophageal cancer with t hree peptides derived from novel cancer-testis antigens. Kono K, Iinuma H et al. J Transl Med 10:141, 2012 (有)

4. Development of minimal residual cancer cell research. Iinuma H, Watanabe T. Nihon GekaGakkaiZasshi 113:177-184, 2012 (有)

5. Chromosomal instability(CIN) phenotype, CIN high or CIN low, predicts survival for colorectal cancer. Watanabe T, Iinuma H et al. J ClinOncol 30:2256-2264, 2012 (有)

6. Increased Risk for CRC in Diabetic Patients eith the Nonrisk Allele of SNPs at 8q24. Ishimaru S, Iinuma H et al. Ann Surg Oncol 19:2853-5858, 2012 (有)

7. Clinicopathological and prognostic significance of microRNA-107 and its relationship to DICER1 mRNA expression in gastric cancer. Inoue T, Iinuma H et al. Oncol Rep 27:1759-1764, 2012 (有)

8. Prognostic significance of CTCs and CTCs of tumor drainage vein blood in Dukes’ stage B and C colorectal cancer patients. Shimada R, Iinuma H et al. Oncol Rep 27:947-953, 2012 (有)

9. Prognostic significance of PDCD4 expression and association with microRNA-21 in each Dukes’ stage of colorectal cancer patients. Horiuchi A, Iinuma H et al. Oncol Rep 27:1384-1392, 2012 (有)

10. Clinical significance of circulating tumor cells, including cancer stem-like cells, inperipheral blood for recurrence and prognosis in patients with Dukes’ stage B and C colorectal cancer.IinumaH,Watanabe
T et al. J ClinOncol 29:1547-1555, 2011 (有)

11. Replay to B. Faltas et al. IinumaH,Watanabe T et al. J ClinOncol 29:2947-2948, 2011 (有)

12. Replay to F.Corea et al. IinumaH,Watanabe T et al.J ClinOncol 29:3488-3489, 2011 (有)

13. Radiation-induced apoptosis of peripheral blood lymphocytes is correlated with histological regression of rectal cancer in response to preoperative chemoradiotherapy. Ishihara S, Iinuma H et al. Ann SurgOncol 19:1192-1198, 2011 (有)

14. Is CD133 mRNA expression a prognostic factor in colorectal cancer?HayamaT, Watanabe T, Iinuma H. J SurgOncol 104:110, 2011 (有)

15. Clinical significance of intraperitoneal CD44 mRNA levels of magneticallyseparated CD45-negativeEpCAM-positive cells for peritoneal recurrence and prognosis in stage II and III gastric cancer patients. Horikawa M, Iinuma H et al Oncol Report 25:1413-1420, 2011 (有)

16. Perforation of the small bowel due to metastasis from tongue cancer. Aoyagi Y, Iinuma H, Watanabe T et al.IntSurg 96:90-93, 2011 (有)

17. Invasive micropapillary carcinoma of the ascending colon–a report of a case. Shibuya H, Iinuma H, Watanabe T et al.Int Surg 96:82-86, 2011(有)

18. Two cases of diverticulitis in patients with Williams syndrome. Yamada H, IinuamH, Watanabe T et Int Surg 96:64-68, 2011 (有)

19. Predicting ulcerative colitis-associated colorectal cancer using reverse-transcription polymerase chain reaction analysis. Watanabe T, Iinuma Het al.Clin Colorectal Cancer 10: 134-141,2011 (有)

20. Heterogeneity of KRAS status may explain the subset of discordant KRAS status between primary and metastatic colorectal cancer. Watanabe T, Iinuma Het al.Dis Colon Rectum 54:1170-1178, 2011 (有)

21. Gene expression of vascular endothelial growth factor A, thymidylate synthase, andtissue inhibitor of metalloproteinase 3 in prediction of response to bevacizumab treatment in colorectal cancer patients. Watanabe T, Iinuma Het al. Dis Colon Rectum 54:1026-1035, 2011 (有)

22. Gene expression signature and response to the use of leucovorin, fluorouracil and oxaliplatin in colorectal cancer patients.Watanabe T, Iinuma H et alClinTranslOncol 13:419-425, 2011 (有)

23. Differential gene expression signatures between colorectal cancers with and without KRAS mutations: crosstalk between the KRAS pathway and other signalling pathways. Watanabe T, Iinuma H et al.Eur J Cancer 47:1946-54, 2011 (有)

24. Usefulness of the mononucleotide marker “BAT-26” for identification of microsatellite instability in colorectal cancers. Watanabe T, Iinuma H et al.Asian Pac J Cancer Prev. 12 :335, 2011 (有)

25. RUNX3 copy number predicts the development of UC-associated colorectal cancer. Watanabe T, Iinuma H et al.Int J Oncol 38:201-207, 2011 (有)

26. Significance of microsatellite instability (MSI) for colorectal cancer following adjuvant therapy with doxifluridine.WatanabeT,Hayama T, IinumaH et al.Med Oncol, 2011 (有)

27. Gene expression of mesenchyme forkhead 1 (FOXC2) significantly correlates with the dedree of lymphnode metastasis in colorectal cancer. Watanabe T, Iinuma H et al. IntSurg 96:207-216, 2011 (有)

28. The prognostic significance of isolated tumor cells in the lymph nodes of gastric cancer patients. FukagawaT, Iinuma H et al. Gastric Cancer 13:191-196,2010 (有)

29. Serum matrix-metalloproteinase-1 is a bona fide prognostic marker for colorectal cancer..Tahara K, Iinuma H et al. Ann SurgOncol, 17:3362-33629, 2010 (有)

30. Association of plasma VEGFR-A, soluble VEGFR-1 and VEGFR-2 levels and clinical response and survival in advanced colorectal cancer patients receiving brvacizumab with modified FOLFOX6. Aoyagi T, Iinuma H, Watanabe T,Oncol Letter, 1 (有)

31. Predictive value of cancer stem-like cells and cancer-associated genetic markers for peritoneal recurrence of colorectal cancer in patients after curative surgery. Nakamura,Iinuma H, Watanabe T Oncology 78:309-315,2010 (有)

32. A case of fulminant amebic colitis with multiple large intestinal perforations.
YamadaH,IinumaH, Watanabe T. IntSurg 95:356-359, 2010 (有)

33. Clinicopathological and prognostic value of microRNA-21 and microRNA-155 in colorectal cancer. Shibuya H, IinumaH, Watanabe T. Oncology 79:313-320, 2010 (有)